Based on the two waves of the Health and professional career survey (HPC), this article examines workers' exposure to psychosocial risks (PSR) and changes in this exposure between 2006 and 2010, in a context of economic crisis. Using Probit models, we estimated an individual's likelihood of exposure to different PSR, conditional upon the socioeconomic traits of individuals and the characteristics of their employment. While overexposure to PSR was generally observed among individuals aged 35 to 44 with a baccalaureate level qualification or exposed to physical hardship, exposure profiles appeared to be clearly differentiated according to gender, occupational category and business sector. Identification of these overexposures and profiles should enable more effective targeting of prevention policies towards these populations which are not always considered to be the most vulnerable in the labour market. A general increase in exposure to PSR was observed over the period 2006-2010. The most striking increase was in the lack of recognition. We analysed these trends according to the economic characteristics of business sectors, whether or not a redundancy programme was in place within the enterprise, and the professional mobility of individuals. No significant link was noted between changes in exposure to PSR and sectoral differences in terms of crisis exposure. However, we highlighted a significant link between the existence of a redundancy programme within the enterprise and increased exposure to PSR. Finally, having professional mobility was coupled with a significant reduction in exposure to PSR. Due to the pro-cyclical nature of external professional mobility, this link may constitute a connection channel between economic crisis and exposure to PSR.